Table 4.
Association of time period with the number of positive lymph nodes in patients with vulvar squamous cell carcinoma and > 10 lymph nodes dissected living in northern Italy (n = 437).
| Decade | Number of positive lymph nodes | |||||
|---|---|---|---|---|---|---|
| 0–1 (n = 320) | ≥ 2 (n = 117) | Odds ratio (95% CI)a | 0–2 (n = 363) | ≥ 3 (n = 74) | Odds ratio (95% CI)a | |
| 1980s | 47 | 19 (28.8) | 1.00 (reference category) | 53 | 13 (19.7) | 1.00 (reference category) |
| 1990s | 73 | 31 (29.8) | 1.26 (0.60–2.65) | 84 | 20 (19.2) | 1.09 (0.48–2.50) |
| 2000s | 111 | 36 (24.5) | 0.78 (0.39–1.58) | 123 | 24 (16.3) | 0.77 (0.35–1.70) |
| 2010s | 89 | 31 (25.8) | 0.79 (0.38–1.63) | 103 | 17 (14.2) | 0.67 (0.29–1.53) |
| P = 0.46b | P = 0.24b | |||||
aSimultaneously adjusted for patient age, tumour size, disease location and depth of stromal invasion.
bChi-square test for trend. CI, confidence interval.