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. 2021 Mar 11;11:5648. doi: 10.1038/s41598-021-85048-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Changes in CYP metabolising ratios during chemotherapy for breast cancer. The change in CYP2C9 (n = 8), CYP2C19 (n = 9), CYP2D6 (n = 8) and CYP3A4 (n = 9) metabolising activity was determined by comparing the probe drug to metabolite ratios from after chemotherapy to before chemotherapy (log10). Horizontal black solid lines represent median values. Horizontal black dotted line represents no change in CYP metabolising activity from baseline to paclitaxel dose six, and points above or below the red dotted horizontal lines represent a decrease or increase, respectively, in CYP metabolising activity of 1.25-fold or greater (log10 of 0.80–1.25 = ± 0.097) from before chemotherapy to after chemotherapy. Statistical analysis was performed using Wilcoxon matched-pairs signed rank testing, and significance was determined as p < 0.05.