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. 2021 Mar 11;11:5648. doi: 10.1038/s41598-021-85048-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Change in circulating inflammatory cytokines measured during chemotherapy. Inflammatory cytokines ANG2, BAFF, CRP, GDF-15, IL-10, and MCP-1 were measured in participant serum using enzyme-linked immunosorbent assays before chemotherapy (n = 10), and after chemotherapy (after paclitaxel dose six; n = 10). Black horizontal solid lines represent median values. The black horizontal dotted line represents no difference in cytokine concentration from baseline to paclitaxel dose six, and points above or below the dotted line represent an increase or decrease in cytokine concentration during chemotherapy, respectively. Statistical analysis was performed using the Wilcoxon matched-pairs signed rank test. *p < 0.05; **p < 0.01.