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. 2021 Mar 11;11:5648. doi: 10.1038/s41598-021-85048-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation between changes in serum MCP-1 and changes in CYP3A4 metabolising activity during chemotherapy. The change in MCP-1 cytokine concentrations from before to after chemotherapy (log10), was correlated with the change in CYP3A4 metabolising activity from before to after chemotherapy (log10; n = 9). Black solid lines represent linear regression line of best fit. Horizontal black dotted lines represent no change in CYP3A4 metabolising activity from baseline to paclitaxel dose six, and points above or below this represent a decrease or increase in CYP3A4 metabolising activity, respectively. Statistical analysis was performed using Spearman correlation analysis, and significance was determined as p ≤ 0.05.