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. 2021 Feb 26;12:630387. doi: 10.3389/fneur.2021.630387

Table 2.

Summary of results for the different fitting methods, with and without an external proton-density-weighted fat fraction (FF) constraint.

Method FF Constraint # echoes wT2 (ms) FF (%) Global FF
error (p.p.)
Volunteers Patients Vol. Pat.
Average Global SD Pooled SD Intrasubject SD Average Global SD Pooled SD
EPG No 3 28.6 1.3 8.1 1.0 31.4 6.2 12 17.3 22.5 6.4
5 34.2 1.8 5.2 1.1 37.7 7.7 8.8 2.9 8.1 −8.0
8 33.8 1.8 4.4 1.0 36.1 4.9 7.6 3.2 9.8 −7.0
17 33.0 1.3 3.3 0.9 32.7 2.5 4.1 4.6 12.8 −4.7
Yes 3 34.5 1.5 5.9 1.5 34.5 3.6 8.9 6.4* 17.8*
5 32.3 1.3 4.9 1.1 32.2 3.2 6.4
8 31.9 1.4 4.9 1.3 32.4 2.6 5.9
17 32.1 1.6 5.1 1.4 33.1 2.5 6.2
Double exponential No 5 25.3 2.9 8.3 3.1 24.7 2.5 10.1 17.9 23.9 8.6
8 29.4 1.7 5.8 1.8 28.4 3.1 6.7 15.1 21.9 6.2
17 33.2 1.6 4.6 1.6 31.7 3.7 9.5 11.9 19.0 3.2
Yes 5 36.1 2.1 6.9 2.3 35.4 3.6 8.3 6.4* 17.8*
8 38.6 2.5 7.7 2.7 38.4 3.7 9.3
17 41.3 3.5 10.4 3.5 41.2 6.2 14

The pooled standard deviation (SD) is associated with image noise, whereas the intrasubject SD is associated with homogeneity in different anatomical regions. The FF error with respect to the multi-echo gradient-echo acquisition (MEGE) is given in percentage points (p.p.). Values marked with an asterisk (*) are not fitted by the algorithm but are derived from the MEGE acquisition.