FIGURE 2.

Circ‐ERBB2 was upregulated in lung cancer tissues and cells. (a) The heat map showed abnormally expressed circRNAs in lung cancer tissues and normal tissues. (b) Circ‐ERBB2 level in lung cancer tissues (n = 31) and adjacent normal tissues (n = 31) was measured by qRT‐PCR. (c) The expression of circ‐ERBB2 in HBE cells and lung cancer cells (SK‐MES‐1, H1650, Calu‐3, H460, H1299 and A549) was examined by qRT‐PCR. (d and e) After RNase R treatment, the levels of circ‐ERBB2 and linear ERBB2 were tested using qRT‐PCR. **p < 0.01, ***p < 0.001, ****p < 0.0001