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. 2021 Mar 12;12(3):263. doi: 10.1038/s41419-021-03527-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A, B A dying cell shows an advanced stage of degeneration. The nucleus shows condensed areas and the cytoplasm results empty due to the presence of a high number vacuoles, some of which containing viral particles (arrows). Numerous viral particles are also visible at the cell membrane (arrowheads). C Cell remnants showing viral particles outside of cell (arrows). D Higher magnification of the boxed area visible in C shows viral particles (arrows). E Lipid droplets (LD) are present inside infected cells, some of which are in contact with mitochondria (arrow). Lipolysosomes (LL) with external membrane and whorls are detected. Mitochondria (m) show swollen cristae. F Viral particles in structures resembling lipolysosomes (LL) are visible (arrowhead). N nucleus, m mitochondria, LD lipid droplets, LL lipolysosomes. Scale bars: A, C = 1 um; D = 100 nm; B, E, F = 200 nm.