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. 2021 Mar 12;12(3):263. doi: 10.1038/s41419-021-03527-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Infected cells show a rough aspect, and many microvillous projections are visible all over the cell surface (arrows). Numerous virus particles are visible at the cell membrane or in the extracellular space (arrowheads). B Cytopathic effect of viral infection generates in a number of cells condensation of cytoplasm and apoptotic cell death (arrow). C Cellular lysis with release of cell material with associated virus particles is observed. D Groups of viral particles were found inside vesicles near the plasma membrane of infected cells (arrows). E Morphological modifications of mitochondria (m) are shown, consisting in swelling with a reduction in membrane cristae amount, leading to the formation of vesicles (arrows). Virus particles are visible inside these vesicles (arrowheads). F SARS-CoV-1 infected cells display the presence of multilamellar structure: at the periphery of the structure ribosome-carrying membrane are visible (arrowheads). N nucleus, m mitochondria. Scale bars: A–C = 1 μm; D–F = 200 nm.