Table 1.
Univariate summary of demographics and outcome variables.
| Total (N = 79) | GBA-NMC (n = 30) | Non-carrier controls (n = 49) | |
|---|---|---|---|
| Demographics | |||
| Age, years, mean (SD), range | 57.63 (12.53), 22–89 | 53.93 (14.41), 29–89 | 59.90 (12.58), 22–86 |
| Median (IQR) | 60.00 (48.00–66.00) | 59.50 (38.75–63.25) | 61.00 (52.50–68.50) |
| Education, mean (SD) | 17.00 (2.00), 12–20 | 17.13 (1.78), 12–20 | 16.78 (6.23), 12–20 |
| Gender, n(%) Female | 23 (29.1%) | 11 (36.7%) | 12 (24.5%) |
| Family history of PD, n(%) | 24 (30.4%) | 17 (56.7%) | 7(14.3%) |
| Primary analyses | |||
| UPDRS-III, mean (SD), range | 0.72 (1.29), 0.0–5.0 | 0.75 (1.19), 0.0–5 | 0.70 (1.36), 0.0–5.0 |
| MoCA total score, mean (SD), range | 27.72 (1.89), 21–30 | 27.60 (2.06), 23–30 | 27.78 (1.81), 21–30 |
| HVLT-R Recall, z score, mean (SD), range | −0.31 (1.21), −3.22–1.22 | −0.36 (0.85), −1.94 to 1.00 | −0.27 (1.42), −3.22 to 1.22 |
| Stroop Interference, T-score, mean (SD), range | 49.00 (6.36), 37–70 | 49.60 (6.57), 37–60 | 48.68 (6.21), 37–70 |
| BDI-II, mean (SD), range ≥ 14, n(%) | 4.22 (5.71), 0–32, 6 (8.7%) | 4.85 (5.17), 0–19, 3 (11.5%) | 3.84 (6.05), 0–32, 3 (7.0%) |
| RBDSQ, mean (SD), range ≥ 5, n(%) | 1.60 (1.67), 0–6, 4 (5.8%) | 2.00 (1.53), 0–6, 1 (4.0%) | 1.36 (1.72), 0–6, 3 (6.9%) |
| UPSIT total correct„ mean (SD), range | 33.06 (5.27), 18–40, 21 (30.9%) | 32.89 (5.23), 18–39, 11 (40.7%) | 33.17 (5.37), 18–40, 10 (24.4%) |
| Hyposmia, n (%) | |||
UPDRS-III, Unified Parkinson's Disease Rating Scale, motor section; MoCA, Montreal Cognitive Assessment; HVLT-R, Hopkins Verbal Learning Test—Revised; BDI-II, Beck Depression Inventory—II; STAI, State Trait Anxiety Inventory; REM Sleep Behavior Disorder Questionnaire; UPSIT, University of Pennsylvania Smell Identification Test.