Table 2.
Promoter methylation frequency (absolute and relative values) by gene and methylation status, in women with and without invasive cervical cancer.
| RARB | CADM | DAPKI | PAXI | |||||
|---|---|---|---|---|---|---|---|---|
| Methylation status | ICC (%) | Normal cervix (%) | ICC (%) | Normal cervix (%) | ICC (%) | Normal cervix (%) | ICC (%) | Normal cervix (%) |
| U | 7 (6.0) | 47 (49.5) | 24 (23.5) | 58 (67.4) | 42 (35.9) | 75 (75.0) | 4 (3.5) | 17 (18.5) |
| MU | 19 (16.4) | 38 (40.0) | 16 (15.7) | 13 (15.1) | 50 (42.7) | 23 (23.0) | 16 (14.0) | 4 (4.3) |
| M | 90 (77.6) | 10 (10.5) | 62 (60.8) | 15 (17.5) | 25 (21.4) | 2 (2.0) | 94 (82.5) | 71 (77.2) |
| M + MU | 109 (94.0) | 48 (50.5) | 78 (76.5) | 28 (32.6) | 75 (64.1) | 25 (25.0) | 110 (96.5) | 75 (81.5) |
| Total | 116 | 95 | 102 | 86 | 117 | 100 | 114 | 92 |
| Comparison: Yates-corrected chi-square value (with P), df = 1; OR (95% CI) | ||||||||
| U vs. MU | 5.33 (0.021) | 3.36 (1.17–9.92) | 5.16 (0.023) | 2.97 (1.14–7.82) | 17.84 (<0.001) | 3.88 (1.199–7.60) | (<0.001)* | 17.00 (3.63–179.69) |
| U vs. M | 85.99 (<0.001) | 60.43 (19.63–197.4) | 39.97 (<0.001) | 9.99 (4.51–22.48) | (<0.001)* | 22.32 (45.03–98.94) | (0.001)* | 5.63 (1.81–17.45) |
| MU vs. M | 13.64 (<0.001) | 3.96 (1.81–8.88) | 3.36 (0.016) | 5.72 (1.21–9.39) | (0.018)* | 5.75 (1.25–26.36) | (0.081)* | 0.33 (0.11–1.03) |
| U vs. [M+MU] | 49.50 (<0.001) | 15.25 (6.06–40.0) | 34.82 (<0.001) | 6.73 (3.38–13.52) | 31.62 (<0.001) | 5.36 (2.86–10.11) | 10.88 (<0.001) | 6.23 (1.87–22.89) |
U, unmethylated promoter; MU, semi-methylated promoter; M, methylated promoter; ICC, invasive cervical cancer; df, degrees of freedom; OR, odds ratio; CI, confidence interval.
*
Based on Fisher exact test due to insufficient data counts. Italic indicates P values.