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. 2021 Mar 11;11:5637. doi: 10.1038/s41598-021-85051-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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LD Diet switch alone and NNMTi treatment combined with LD switch influence the obesogenic diet-induced EWAT metabolic signature. Heat maps of the sixteen metabolites that demonstrated a significant pairwise comparison between control mice maintained on WD vs. LD; individual mouse results (a) and group averages (b) are displayed for these in the top panels, and the bottom panels include the addition of the individual mouse results (c) and group averages (d) for the WD/LD-V and WD/LD-T groups (n = 6–8/group for all panels). Metabolites were analyzed raw or log transformed, and using a one-way ANOVA, Welch’s ANOVA, or Kruskal–Wallis test. For a full list of statistical results, see Supplementary Table S5. LD lean diet, -T NNMTi-treated, -V vehicle-treated, WD Western diet, b both WD/LD groups vs. LD/LD-V, d WD/LD-T vs. WD/LD-V. Labeled pairwise comparisons are significant (< 0.05) corrected (q) and uncorrected (p) for multiple comparisons; ⁺significant result with FDR correction only.