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. 2021 Mar 11;11:5637. doi: 10.1038/s41598-021-85051-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Impact of NNMTi treatment combined with LD switch on EWAT metabolome and associated pathways regulated in DIO mice. Schematic illustration of pathways modulated by NNMTi treatment independently or in conjunction with diet switch. 1-MNA 1-methylnicotinamide, AA amino acid, Ac-CoA acetyl-coenzyme A, AMPK adenosine monophosphate kinase, BCAA branched-chain amino acid, F-6-P fructose-6-phosphate, FA fatty acid, FOXO forkhead box protein O, Glut4 glucose transporter type 4, G-1-P glucose-1-phosphate, G-6-P glucose-6-phosphate, NAD nicotinamide adenine dinucleotide, NAM nicotinamide, NAMPT nicotinamide phosphoribosyltransferase, NF-κB nuclear factor-kappa B, NMN nicotinamide mononucleoside, NMNAT nicotinamide adenylyltransferase, NNMT nicotinamide N-methyltransferase, -O oxidation, PGC-1 α peroxisome proliferator-activated receptor (PPAR) gamma coactivator 1-alpha, SAH S-adenosyl-L-homocysteine, SAM S-adenosyl-L-methionine, Sirts sirtuins, SIRT1 (NAD-dependent deacetylase) sirtuin 1, TCA tricarboxylic acid.