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IPA of the EWAT metabolome predicts inhibition of lipid synthesis as a major mechanistic pathway differentially modulated by NNMTi treatment relative to diet switch alone. IPA included all metabolites measured in the WD/LD-T group relative to the WD/LD-V group and predicted that lipid synthesis was inhibited with NNMTi treatment (p = 0.045, activation z-score = − 2.5660).
