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. 2021 Feb 26;12:640241. doi: 10.3389/fphar.2021.640241

TABLE 10.

Calculated pharmacokinetic measures for psilocin.

Psilocybin dose (mg/kg) (mean ± SD)
0.5 mg/kg 0.1 mg/kg 1 mg/kg 10 mg/kg
tmax (h) 0.6 ± 0.4 0.54 ± 0.3 0.57 ± 0.3 0.71 ± 0.3
Cmax (ng/mL) 7.14 ± 4.0 11.7 ± 6.8 83.3 ± 14.4 1106 ± 434
Apparent t1/2 (h) 1.00±0.20 0.92 ± 0.20 0.88 ± 0.10 1.70 ± 0.30
AUC0-tlast (h*ng/mL) 10.1 ± 4.0 12.5 ± 6.4 117.0 ± 45.2 2280 ± 1524
AUC0-inf (h*ng/mL) 10.3 ± 3.9 15.7 ± 5.6 143.0 ± 20.4 3376 ± 1056
MRT0-inf (h) 1.73 ± 0.20 1.42 ± 0.30 1.53 ± 0.10 2.70 ± 0.40