TABLE 2.
Performance measures from 5-choice serial reaction time task: Standard conditions of 0.75 s SD, 5 s ITI, 100 trials. Data is presented for all rats treated with ketamine (N = 36) or Psilocybin (N = 24). *p < 0.05 vs. vehicle.
| Treatment | #Correct trails | #Incorrect trails | #Missed trails | % Correct | % Hit | PREM | PSV | Correct latency (s) | Magazine latency (s) | Total trails |
|---|---|---|---|---|---|---|---|---|---|---|
| Vehicle | 69.5 ± 2.8 | 12.7 ± 1.3 | 6.1 ± 1.2 | 84.2 ± 1.7 | 78.6 ± 2.1 | 9.0 ± 1.4 | 25.1 ± 2.0 | 0.41 ± 0.01 | 1.38 ± 0.09 | 88.3 ± 2.4 |
| Ketamine (0.3 mg/kg) | 71.3 ± 2.1 | 13.9 ± 1.3 | 6.2 ± 1.1 | 83.3 ± 1.6 | 77.9 ± 1.2 | 7.4 ± 1.0 | 29.0 ± 2.5 | 0.42 ± 0.01 | 1.50 ± 0.11 | 86.9 ± 3.7 |
| Ketamine (1 mg/kg) | 70.6 ± 2.7 | 11.7 ± 1.1 | 7.0 ± 1.3 | 85.5 ± 1.5 | 78.7 ± 2.0 | 8.4 ± 1.5 | 25.4 ± 2.4 | 0.42 ± 0.01 | 1.33 ± 0.07 | 83.9 ± 4.1 |
| Ketamine (3 mg/kg) | 68.0 ± 3.1 | 11.1 ± 1.4 | 8.6 ± 1.5 | 85.4 ± 1.9 | 76.7 ± 2.5 | 9.2 ± 1.7 | 28.9 ± 2.6 | 0.40 ± 0.01 | 1.26 ± 0.08 | 87.7 ± 2.1 |
| Ketamine (6 mg/kg) | 53.8 ± 3.6* | 10.0 ± 1.0 | 18.5 ± 2.4* | 83.0 ± 1.8 | 65.5 ± 3.1* | 14.0 ± 2.3* | 40.3 ± 4.5* | 0.34 ± 0.01* | 1.05 ± 0.12 | 82.3 ± 2.8 |
| Vehicle | 67.8 ± 3.8 | 11.1 ± 1.1 | 15.41 ± 2.5 | 85.2 ± 1.5 | 71.3 ± 3.1 | 5.1 ± 0.8 | 20.8 ± 2.3 | 0.73 ± 0.03 | 3.04 ± 0.38 | 94.1 ± 2.3 |
| Psilocybin (0.05 mg/kg) | 72.1 ± 3.6 | 9.6 ± 1.2 | 14.5 ± 2.4 | 87.5 ± 1.6 | 74.5 ± 2.8 | 5.2 ± 0.9 | 21.3 ± 3.1 | 0.69 ± 0.03 | 3.42 ± 0.66 | 96.1 ± 2.7 |
| Psilocybin (0.1 mg/kg) | 70.0 ± 3.2 | 9.8 ± 1.2 | 15.8 ± 2.8 | 87.7 ± 1.5 | 73.4 ± 2.8 | 5.9 ± 1.1 | 25.5 ± 3.7 | 0.70 ± 0.03 | 3.97 ± 0.94 | 95.7 ± 2.4 |