TABLE 4.
Performance measures from 5-choice serial reaction time task: Standard conditions of 0.75 s SD, 5 s ITI, 100 trials. Psilocybin “low” and “high” performers (N = 8 per subgroup).
| Subgroup | Treatment | #Correct trials | #Incorrect trials | #Missed trials | %Correct | %Hit | PREM | PSV | Correct latency (s) | Magazine latency (s) | Total trials |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Low performers | Vehicle | 53.5 ± 6.2 | 15.8 ± 1.9 | 18.8 ± 5.8 | 76.9 ± 2.1 | 60.6 ± 5.5 | 5.6 ± 1.5 | 29.3 ± 2.7 | 0.83 ± 0.07 | 3.16 ± 0.44 | 88.0 ± 5.1 |
| Psilocybin (0.05 mg/kg) | 62.4 ± 7.6* | 13.0 ± 2.5 | 14.4 ± 5.4 | 81.8 ± 3.2* | 69.1 ± 5.3* | 6.5 ± 1.6 | 30.3 ± 6.5 | 0.72 ± 0.04* | 4.77 ± 1.88 | 89.8 ± 7.7 | |
| Psilocybin (0.1 mg/kg) | 61.9 ± 5.1* | 13.5 ± 2.1 | 14.3 ± 4.9 | 82.5 ± 1.9* | 70.3 ± 4.6* | 8.3 ± 2.7 | 35.1 ± 7.9 | 0.76 ± 0.05* | 6.51 ± 2.66 | 89.6 ± 6.9 | |
| High performers | Vehicle | 82.4 ± 3.0 | 6.4 ± 0.4 | 11.3 ± 3.0 | 92.8 ± 0.5 | 82.4 ± 3.0 | 5.0 ± 1.7 | 12.5 ± 2.0 | 0.63 ± 0.03 | 2.18 ± 0.18 | 100.0 ± 0.0 |
| Psilocybin (0.05 mg/kg) | 81.9 ± 2.4 | 7.4 ± 1.8 | 10.8 ± 1.8 | 91.8 ± 1.9 | 81.9 ± 2.4 | 5.0 ± 1.8 | 14.3 ± 2.5 | 0.64 ± 0.03 | 2.37 ± 0.18 | 100.0 ± 0.0 | |
| Psilocybin (0.1 mg/kg) | 78.6 ± 4.7 | 6.8 ± 1.9 | 12.6 ± 2.7 | 91.9 ± 2.2 | 79.9 ± 3.9 | 3.3 ± 1.4 | 16.3 ± 4.7 | 0.66 ± 0.04 | 2.53 ± 0.22 | 98.0 ± 1.6 |