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. 2021 Feb 26;11:607021. doi: 10.3389/fonc.2021.607021

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Copyright © 2021 Liu, Chen, Li, Zhang, Kong, Wang, Bai and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PSMC2 is highly expressed in HCC tumors and correlated with overall survival and disease-free survival for HCC patients. (A) PSMC2 immunostaining in TMAs are shown. Note: top panel, scale 500 μm; bottom panel, scale 50 μm. (B) The distribution of the difference in staining intensities of PSMC2 in HCC tissues compared with corresponding adjacent noncancerous tissue. N, paired adjacent noncancerous tissues. C, HCC tissues. PSMC2 expression levels were significantly higher in HCC compared with corresponding adjacent noncancerous tissues (Wilcoxon test, P < 0.001). (C) High PSMC2 expression is associated with poorer overall survival (P = 0.004, log-rank test) and disease-free survival for HCC patients (P = 0.035, log-rank test).