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Downregulation of p21 reverses the inhibition of proliferation and cell cycle induced by PSMC2 knockdown. (A) PSMC2 and p21 knockdown in MHCC97-L stable cells was confirmed at the protein level by western blotting. (B–D) The inhibition of proliferation and cell cycle caused by PSMC2 knockdown was regressed by transient transfection of p21 siRNA in MHCC97-Lstable cells. Data are shown as mean ± standard deviations from three independent experiments. **P < 0.01, ***P < 0.001.
