Table 1.
Anthropometric and Biochemical Parameters of All Studied Animal Groups.
Group I negative control N = 10 | Group II nontreated NAFLD group model N = 11 | Group III positive control group N = 10 | Group IV NAFLD + vitamin D supplement N = 14 | ANOVA P value | |
---|---|---|---|---|---|
Weight (gm) | 194.80 ± 1.81 | 343.55 ± 5.80a | 199.70 ± 2.68b | 337.71 ± 3.72a,c | <0.001 |
Height (cm) | 21.26 ± 0.45 | 21.49 ± 0.32 | 21.23 ± 0.26 | 21.26 ± 0.34 | 0.94 |
BMI (gm/cm2) | 0.43 ± 0.06 | 0.74 ± 0.07c | 0.44 ± 0.03a,b | 0.72 ± 0.07a,b | <0.001 |
Hepatic index | 0.05 ± 0.001 | 0.04 ± 0.001a | 0.05 ± 0.001b | 0.04 ± 0.001a,c | <0.001 |
Insulin (μu/L) | 25.54 ± 0.93 | 35.72 ± 0.92a | 24.56 ± 1.69b | 36.56 ± 1.10a,c | <0.001 |
Glucose (mmol/L) | 5.28 ± 0.35 | 7.88 ± 0.28a | 4.69 ± 0.26b | 7.72 ± 0.22a,c | <0.001 |
HOMA-IR | 0.33 ± 0.03 | 0.69 ± 0.03a | 0.28 ± 0.03b | 0.69 ± 0.03a,c | <0.001 |
T Chol. (mmol/L) | 2.73 ± 0.23 | 4.71 ± 0.30a | 2.82 ± 0.23b | 4.59 ± 0.38a,c | <0.001 |
TG (mmol/L) | 1.04 ± 0.08 | 1.33 ± 0.21a | 1.00 ± 0.09b | 1.23 ± 0.23a,c | 0.001 |
LDL-C (mmol/L) | 1.19 ± 0.17 | 2.34 ± 0.74a | 1.00 ± 0.09b | 1.72 ± 0.44a,c | 0.001 |
HDL-C (mmol/L) | 1.07 ± 0.10 | 1.53 ± 0.30a | 1.01 ± 0.09b | 1.89 ± 0.77a,c | <0.001 |
Albumin (g/dl) | 3.51 ± 0.02 | 3.41 ± 0.04 | 3.46 ± 0.02 | 3.48 ± 0.02 | 0.16 |
AST (U/L) | 44.75 ± 1.03 | 57.07 ± 0.82a | 45.62 ± 0.73b | 56.66 ± 1.18a,c | <0.001 |
ALT (U/L) | 35.57 ± 0.76 | 46.34 ± 0.59a | 35.41 ± 0.56b | 45.57 ± 0.70a,c | <0.001 |
ALP (U/L) | 67.64 ± 1.10 | 66.58 ± 1.79 | 70.45 ± 1.51 | 64.40 ± 1.66 | 0.15 |
GGT (U/L) | 8.97 ± 0.13 | 13.55 ± 0.30a | 9.25 ± 0.12b | 13.00 ± 0.34a,c | <0.001 |
25 OHD3 (nmol/l) | 13.24 ± 0.23 | 7.16 ± 0.37a | 14.36 ± 0.36b | 10.04 ± 0.26a,b,c | <0.001 |
SMP-30 (pg/ml) | 117.20 ± 0.87 | 83.21 ± 0.81a | 116.70 ± 1.19b | 84.18 ± 0.76a,c | <0.001 |
Data are presented as mean ± standard deviation.
Statistical analysis was carried out using one-way analysis of variance (ANOVA) followed by Tukey's post-hoc analysis.
Significantly different from N.C value at P < 0.05.
Significantly different from NAFLD value at P < 0.05.
Significantly different from N.C + Vit D value at P < 0.05.