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. 2021 Feb 26;10:592811. doi: 10.3389/fonc.2020.592811

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Copyright © 2021 Dong, Song, Chen, Qi, Jiang, Li, Zheng, Wang, Zhang and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of tumor microenvironment scores with BTLA expression profiles and the relative proportion and correlation of tumor-infiltrating immune cells in SKCM. (A) Spearman correlations between BTLA and microenvironment scores calculated based on the ESTIMATE algorithm in primary and metastatic SKCM. (B, C) Heatmap illustrating the proportion of the immune cells in primary and metastatic SKCM microenvironment using xCell and CIBERSORT. (D, E) Correlation clustering of immune cells based on expression data to classify them into four groups by xCell and CIBERSORT.