Table 2.
Animal studies of different probiotic strains effects in modulating inflammation.
| Reference | Probiotic strain | Doses | Studied model | Effect on cytokine patterns and inflammatory mediators |
|---|---|---|---|---|
| L. Chen et al. (100) | L. acidophilus | 1 × 104, 1 × 105, 1 × 106, 1 × 107 1 × 108 CFU/10 g body weight/day |
DSS-induced colitis in mice | ↓ IL-17, IL-23, TGFβ1 and TNF-α |
| C. Gao et al. (101) | L. reuteri ATCC PTA6495 | 5 × 109 CFU/day | TNBS-induced colitis in mice | ↓ IL-1β, IL-6 Activation histamine H2-receptor |
| T. Kanda et al. (104) | E. durans TN-3 | 10 mg/day | DSS-induced colitis in mice | ↑ Treg and IL-10 ↓ IL-1β, IL-6, IL-17A and IFN-γ |
| C. dogi et al. (105) | L. rhamnosus RC007 | 1 × 107 cells/day | TNBS- induced colitis in mice | ↑ IL-10/TNF-α ratio |
| B. K. Thakur et al. (66) | L. casei Lbs2 | 1 × 109 CFU/day | TNBS-colitis-induced in mice | ↑ Treg |
| A. Rodríguez-Nogales et al. (103) |
L. fermentum CECT5716 L. salivarius CECT5713 |
5 × 108 CFU/day | DSS-induced colitis in mice | ↓ IL-1β, IL-12 and TGF-β ↓ NOS |
| H. Mi et al. (108) | BB. Infantis | 1 × 109 CFU/day | colorectal cancer induced by dimethylhydrazine in mice | ↓ IL-2, IL-12, and IFN-γ |
| Y. Tang et al. (107) |
B. breve DM8310 L. acidophilus DM8302 L. casei DM8121 S. thermophilus DM8309 |
1 × 108 1 × 109 CFU/Kg/day |
5-FU-induced mucositis in mice | ↓ IL-6 and TNF-α |
| J. S. ParK et al. (97) | L. acidophilus | 8 × 108 CFU/Kg/day | DSS-induced colitis in mice | ↑ Treg and IL-10 ↓ IL-17 |
| CFU/10 g body | ||||
| X. Zhou et al. (98) | L. fermentum CQPC04 | 1.5 × 109 5 × 1010 CFU/Kg/day |
DSS-induced colitis in mice | ↑ IL-10 ↓ TNF-α, IFN-γ, IL-1β, IL-6, and IL-12 Inhibited NF-κBp65, COX-2 |
| S. H. Choi et al. (99) | L. plantarum CAU1055 | 8 × 109 CFU/day | DSS-induced colitis in mice | ↓ TNF-α and IL-6 ↓ NOS and COX-2 |
| L. Huang et al. (106) | L. plantarum C88 | 4 × 1010 CFU/Kg/day | aflatoxin B1-induced liver injury in mice | ↓ IL-1β, IL-6, IL-8, TNF-α and IFN-γ Inhibited NF-κB |
| M. Liu et al. (2019) | L. lactis ML2018 | 1 × 108 CFU/day | DSS-induced colitis in mice | ↓ NF-κB and MAPK |
| V. Sagheddu et al. (76) | L. reuteri LMG P-2748 | 1 × 109 CFU/day | C. difficile induced colitis in mice | ↑ IL-10 |