Table 3. Changes in the heart rate from baseline.

	Placebo	Low-dose carvedilol ER	High-dose carvedilol ER	p value#
Week 2	0.7 ± 7.6	-3.6 ± 8.3	-1.9 ± 10.8	0.092
	p = 0.565	p = 0.007	p = 0.240
Week 4	0.5 ± 8.3	-4.0 ± 7.5	-6.5 ± 11.1	0.002
	p = 0.680	p = 0.001	p < 0.001
Week 8	-1.2 ± 9.9	-8.4 ± 9.0	-8.6 ± 11.0	< 0.001
	p = 0.449	p < 0.001	p < 0.001

* Data were based on the safety population. ^# Between-group differences were compared by the analysis of variance model.

ER, extended-release.