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. 2021 Mar 5;14(5):42. doi: 10.3892/br.2021.1418

Table IV.

Comparison of nanoparticles and fine particles in drug delivery systems.

Nanoparticles Fine particles
Increased bioavailability Low bioavailability
Dose proportionality Potential toxic effects
Decreased toxicity Larger and unstable dosage form
Smaller dosage form Low agent surface area hence low dissolution rate
Large agent surface area hence high dissolution rate