Figure 1.

Molecular algorithms previously reported that utilize (a) penA without mosaicism determination, (b) penA with mosaicism determination, (c) non-penA without mosaicism determination and (d) non-penA with mosaicism determination. Sensitivity and specificity values are for decreased susceptibility to ceftriaxone. Sensitivity was calculated by dividing the number of isolates with decreased susceptibility to ceftriaxone with the targeted genetic modification by the total number of isolates with decreased susceptibility to ceftriaxone. Specificity was calculated by dividing the number of isolates with susceptibility to ceftriaxone without the targeted genetic modification by the total number of isolates with susceptibility to ceftriaxone. Testing for all genetic loci in these algorithms is intended to be done simultaneously and not necessarily in a step-wise fashion. An asterisk indicates that no decreased susceptible strains have been reported with this combination of amino acid alterations.