Table III.
Urine and Blood Concentrations From Authentic Samples in This Study
| Urine results | Blood results | |||||||
|---|---|---|---|---|---|---|---|---|
| Intake classification | Analytes | N | Concentration range (µg/mL) | Median (µg/mL) |
N | Concentration range (µg/g) | Median (µg/g) |
|
| Codeine intake N = 42 | M3G | 37 | 0.25–77.8 | 1.95 | – | – | – | |
| M6G | 24 | 0.27–12.8 | 0.45 | – | – | – | ||
| NMOR | 27 | 0.06–4.88 | 0.16 | – | – | – | ||
| MOR | 25 | 0.03–3.54 | 0.15 | 14 | 0.005–0.18 | 0.01 | ||
| C6G | 42 | 1.51–398 | 46.4 | – | – | – | ||
| NCOD | 37 | 0.06–34.2 | 0.39 | – | – | – | ||
| COD | 42 | 0.10–36.0 | 2.59 | 42 | 0.006–2.4 | 0.07 | ||
| Metabolite Ratios | Ratio Range | Ratio Median | ||||||
| M3G/MOR | 24 | 1.6–83.2 | 21.9 | – | – | – | ||
| C6G/COD | 42 | 0.5–262 | 22.0 | – | – | – | ||
| Morphine intake N = 49 | M3G | 44 | 0.29–318 | 10.1 | – | – | – | |
| M6G | 37 | 0.29–63.5 | 3.35 | – | – | – | ||
| NMOR | 14 | 0.06–2.10 | 0.13 | – | – | – | ||
| MOR | 46 | 0.05–47.8 | 1.05 | 49 | 0.01–6.9 | 0.07 | ||
| Metabolite Ratios | Ratio Range | Ratio Median | ||||||
| M3G/MOR | 43 | 2.3–70.9 | 9.0 | – | – | – | ||
| Heroin intake N = 36 | M3G | 31 | 0.21–823 | 26.4 | – | – | – | |
| M6G | 29 | 0.22–174 | 4.88 | – | – | – | ||
| NMOR | 14 | 0.05–1.59 | 0.13 | – | – | – | ||
| MOR | 36 | 0.04–97.0 | 3.07 | 36 | 0.02–0.89 | 0.22 | ||
| C6G | 27 | 0.21–77.8 | 2.60 | – | – | – | ||
| NCOD | 10 | 0.05–1.19 | 0.10 | – | – | – | ||
| COD | 31 | 0.04–7.98 | 0.38 | 32 | 0.005–0.12 | 0.02 | ||
| 6-MAM | 36 | 0.02–25.6 | 0.47 | 16 | 0.005–0.03 | 0.02 | ||
| Metabolite Ratios | Ratio Range | Ratio Median | ||||||
| M3G/MOR | 32 | 1.3–33.5 | 6.4 | – | – | – | ||
| C6G/COD | 27 | 1.2–32.7 | 6.0 | – | – | – | ||