Table 4.
. Predictors of MODS development in univariable and multivariable Cox regression analyses.
| Variables | Univariable |
Multivariable |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Age | 1.047 | 1.033–1.062 | <0.001 | |||
| Gender (male) | 1.640 | 1.152–2.335 | 0.006 | |||
| Smoking | 2.630 | 1.788–3.867 | <0.001 | |||
| Comorbidity | ||||||
| CHD | 1.752 | 1.141–2.691 | 0.010 | |||
| Hypertension | 1.990 | 1.420–2.790 | <0.001 | |||
| Diabetes | 2.816 | 2.010–3.945 | <0.001 | 3.353 | 1.640–6.856 | 0.001 |
| Time of illness onset | 1.033 | 1.005–1.062 | 0.020 | |||
| Blood routine index | ||||||
| WBC | 1.135 | 1.109–1.161 | <0.001 | |||
| Neutrophil | 1.140 | 1.115–1.167 | <0.001 | |||
| Neutrophil% | 1.096 | 1.076–1.116 | <0.001 | |||
| Lymphocyte | 0.103 | 0.058–0.183 | <0.001 | |||
| Lymphocyte% | 0.879 | 0.856–0.902 | <0.001 | |||
| Monocyte | 1.615 | 1.101–2.369 | 0.014 | |||
| Monocyte% | 0.830 | 0.786–0.876 | <0.001 | |||
| Hemoglobin | 0.993 | 0.987–1.000 | 0.058 | 0.984 | 0.972–0.997 | 0.016 |
| Platelet | 0.994 | 0.992–0.996 | <0.001 | |||
| Coagulation function | ||||||
| PT | 1.037 | 1.024–1.049 | <0.001 | 1.050 | 1.022–1.079 | <0.001 |
| D-Dimmer | 1.087 | 1.067–1.108 | <0.001 | |||
| Biochemical indexes | ||||||
| CTnI | 1.425 | 1.204–1.688 | <0.001 | |||
| NT-proBNP | 2.421 | 2.035–2.881 | <0.001 | 2.424 | 1.660–3.541 | <0.001 |
| ALT | 1.003 | 1.002–1.005 | <0.001 | |||
| AST | 1.002 | 1.001–1.003 | <0.001 | |||
| Albumin | 0.876 | 0.848–0.905 | <0.001 | |||
| Globulin | 1.016 | 0.994–1.038 | 0.153 | |||
| HDL-C | 0.091 | 0.037–0.221 | <0.001 | |||
| LDL-C | 0.535 | 0.388–0.738 | <0.001 | |||
| CK | 1.000 | 1.000–1.001 | <0.001 | |||
| LDH | 1.002 | 1.002–1.003 | <0.001 | |||
| Creatinine | 1.002 | 1.001–1.003 | <0.001 | |||
| Immuno-inflammatory indices | ||||||
| IL-6/LY | 8.487 | 5.032–14.314 | <0.001 | 4.143 | 1.321–12.986 | 0.015 |
| NLR | 1.042 | 1.035–1.050 | <0.001 | |||
| Hs-CRP | 1.009 | 1.007–1.011 | <0.001 | |||
| ESR | 1.002 | 0.995–1.010 | 0.514 | |||
| Ferritin | 5.733 | 3.674–8.946 | <0.001 | |||
| PCT | 1.029 | 1.016–1.041 | <0.001 | |||
| Alexin C3 | 0.074 | 0.025–0.221 | <0.001 | |||
| Alexin C4 | 0.004 | 0.001–0.073 | <0.001 | |||
| IL-2R | 1.000 | 1.000–1.001 | <0.001 | |||
| IL-6 | 1.001 | 1.000–1.001 | <0.001 | |||
| IL-8 | 1.000 | 1.000–1.001 | 0.005 | |||
| IL-10 | 1.013 | 1.008–1.017 | <0.001 | |||
| TNF-α | 1.046 | 1.034–1.058 | <0.001 | |||
Hazard ratio (HR), confidence interval (CI), multiple organ dysfunction syndrome (MODS), coronary heart disease (CHD), white blood cell count (WBC), prothrombin time (PT), Hypersensitive cardiac troponin I (CTnI), N-terminal pro brain natriuretic peptide (NT-proBNP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), lactate dehydrogenase (LDH), creatine kinase (CK), IL-6 to lymphocyte ratio (IL-6/LY), neutrophil to lymphocyte ratio (NLR), high-sensitivity C-reactive protein (Hs-CRP), erythrocyte sedimentation rate (ESR), procalcitonin (PCT), interleukin-2 receptor (IL-2R), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), tumor necrosis factor α(TNF-α).