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. 2020 Dec 11;153(1):e202012722. doi: 10.1085/jgp.202012722

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© 2020 Nathan et al.

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Figure 10. — Na_V–Na_V dimerization: interaction between CT helix αVI and EFL of an adjacent channel. (a) Front view of the complex of CTNa_V1.5–CaM (red surface) with another channel’s helix αVI (pink ribbons) as observed in PDB accession no. 4OVN. CaM bound to each channel is shown in shades of green. (b) Bird’s eye view of a; the binding site of helix αVI of channel 1 (pink ribbons) on EFL of channel 2 (red surface). (c) Rotated 90° with both channels 1 and 2 shown in ribbons. Na_V1.5 channel 1 is shown in pink with its CaM (light green), and Na_V1.5 channel 2 EFL in red with its CaM (dark green).