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. 2020 Dec 11;153(1):e202012722. doi: 10.1085/jgp.202012722

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© 2020 Nathan et al.

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Figure 5. — Na_V1.4 displays CDI. (a) Na_V1.5 Na⁺ current does not change upon Ca²⁺ release, but Na_V1.4 I_Na is reduced upon optical Ca²⁺ release, indicated with a blue line. (b) When CTNa_V1.4 is transplanted to Na_V1.5 and vice versa, the CDI still only takes place in channels with CTNa_V1.4. (c) Deletion of the Na_V1.5 post-IQ motif reveals CDI with I_Na reduced at 10 µM Ca²⁺. a and b are adapted from Ben-Johny et al. (2014), and c is adapted from Yoder et al. (2019).