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. 2020 Dec 11;153(1):e202012722. doi: 10.1085/jgp.202012722

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© 2020 Nathan et al.

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Figure 8. — Mutations in Na_V1.5 mapped to its structure. (a) Overall structure of Na_V1.5 with the transmembrane portion as observed in the cryo-EM structure (PDB accession no. 6UZ3) in purple. CT domain as observed in PDB accession no. 4OVN, shown in pink surface with mutations displayed in red. (b) Zoom-in showing mutations in the EFL and IQ region, potentially interacting with (or in close proximity to) CaM. (c) Mutations interacting with FHF of PDB accession no. 4JQ0. (d) Mutations of Na_V1.5 in the EFL that line the binding site of the DIII–DIV linker.