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. 2020 Dec 11;153(1):e202012722. doi: 10.1085/jgp.202012722

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© 2020 Nathan et al.

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Figure 9. — Mutations in Na_V1.4 mapped to its structure. (a) Overall structure of Na_V1.4 with the transmembrane portion as observed in the cryo-EM structure (PDB accession no. 6AGF) in purple and Na_V β1 in yellow. CT domain as observed in PDB accession no. 6MBA, shown in orange surface with mutations displayed in white. (b) Different 6MBA Na_V1.4 orientation with FHF (from PDB accession no. 4JQ0 of Na_V1.5 with FHF1b; aligned to 6MBA by CTNa_V EFL) to show a possible interaction with Q1633.