Figure 2.
Virus replication in three late controller and four progressor macaques inoculated with SHIVAD8-EO and administered a 2-wk course of combination bNAb therapy beginning on day 3 PI. (A–G) Plasma virus loads in three late controller macaques (A–C) and four progressor macaques (D–G) are shown over a 140–350-wk period. Red arrows indicate the time of the anti-CD8α–depleting mAb MT807R1 infusions. The three progressors that developed AIDS and were euthanized are indicated (red †). The vertical dotted lines separate the previously reported results (Nishimura et al., 2017) from new data collected during the past 2.5–3.5 yr. IR, intrarectally; IV, intravenously.