Table 3.

Clinical Features of IE Caused by Corynebacteria Compared to Other Organisms

Demographics	Corynebacteria	Staphylococcus aureus	Non-BHS	Enterococcus faecalis
	n = 30	n = 1954	n = 1478	n = 513
Definite IE (%)	87	93	87	90
Age (years, median)	71 (60–76)a	66 (46–79)a	70 (58–80)a	73 (60–81)a
Gender (%male)	77	62	72	77
Underlying disease (%)
Diabetes	39	18	16	18
Cancerb	9	9	10	14
IVDU	0	24***	4	13
Underlying heart disease (%)
Native valve disease	33	14**	35	20
Prosthetic heart valve	70	14****	26****	39**
Previous IE	23	9*	9*	16
Pacemaker/ICD	27	16	8**	17
Type of infection (%)
NVE, left isolated	23	46*	57***	46*
NVE, right isolated	0	21**	2	5
PVE	70	14****	26****	39**
Isolated PME	7	6	1*	4
Aortic valve	70	30****	37***	53
Mitral valve	17	31	30	32
Nosocomial	23	12	4	12
Course of Disease
Onset to hospitalization (days)	7	2****	14	7
Length of stay (days)	42 (32–46)a	33* (27–44)a	29**** (18–37)a	39 (29–46)a
Treatment length (days)	42 (30–46)a	30*** (28–40)a	28**** (26–33)a	37 (28–42)a
Embolization (%)	10	44***	22	23
Onset of admission to operation (days)	8 (3–18)a	13 (7–25)a	11 (6–21)a	14 (6–25)a
Surgery (%)c	50	24**	22***	26*
Mortality (%)d	13	15	5	11

Abbreviations: ICD, intracardiac device; IE, infective endocarditis; IVDU, intravenous drug use; non-BHS, non-beta-hemolytic streptococci; NVE, native valve endocarditis; PME, pacemaker endocarditis; PVE, prosthetic valve endocarditis.

^aInterquartile range.

^bTreatment within treatment the past 5 years.

^cSurgery during treatment.

^dIn-hospital mortality. Continuous data are presented as median and categorical variables as count (percentage). The P values for difference between characteristics of patients with IE caused by corynebacteria compared with patients with S aureus, non-BHS streptococci, or E faecalis, respectively, are indicated as follows:

*, P < .05.

**, P < .01.

***, P < .001.

****, P < .0001.