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. 2021 Mar 11;13:42. doi: 10.1186/s13073-021-00845-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Signal transduction pathway analysis of subnetwork genes reported for 79 patients in 5 subtypes. (From left to right) Blue heatmap: 238 signaling pathways clustered according to proportion of shared subnetwork genes; Orange heatmap: Enrichment significance of pathways in subnetwork genes combined from patients of given subtype. Darker orange indicates higher significance; Purple heatmap: Median difference in matched pathway genes observed in pairwise comparisons of subnetwork gene sets from patients mapped to 33 pathways. Darker purple indicates higher tendency of pairs of subnetwork gene sets to coincide with different pathway genes; Green heatmap: Enrichment significance of pathways in subnetwork genes of 79 patients. Darker green indicates higher significance. Corresponding subtypes and metastatic status are shown by the annotation above the heatmap. A detailed version of this figure capturing pathway and sample names is provided in Additional file 1: Fig. S2