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. 2021 Feb 26;13:648115. doi: 10.3389/fnagi.2021.648115

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Copyright © 2021 Guo, Zhou, Li, Xiao, Zhang, Yang, Feng and Kang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathological and functional alterations after MCAO between young and aged rats. (A) Coronal rat brain sections (2 mm thick) stained with TTC showing the ischemic core. White reflects the infarct area. (B) Changes in brain ischemic infarction area as time elapsed following MCAO between young and aged rats determined by slope-ratio assay. (C) Survival rate calculated by Kaplan–Meier curve at 21 days after MCAO. Sham-operated aged (n = 20) and young rats (n = 20), 100% survival; MCAO young rats (n = 90), 85% survival; and MCAO aged rats (n = 90), 71.1% survival. (D) TUNEL determination in the peri-infarct cortex after MCAO. Data are presented as mean ± SD (n = 4 per group) *p < 0.05 (unpaired t-test). (E) mNSS and corner turn test at 3, 7, 14, and 21 days after MCAO. Data are presented as mean ± SD (n = 3–4 per group). *p < 0.05 (two-way repeated measures ANOVA followed by LSD).