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. 2020 Sep 3;217(12):e20191473. doi: 10.1084/jem.20191473

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© 2020 Macleod et al.

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Figure S5. — T reg cell depletion augments virus clearance from the chronically infected GIT. (A) Mice were infected with LCMV-Arm (acute) or LCMV-Cl13 (chronic), and 35 dpi, T reg cells (CD4⁺Foxp3⁺) from the SI and LI were analyzed by CyTOF. The heatmap shows column-normalized protein expression of PhenoGraph-defined clusters. Clusters significantly increased in frequency (ANOVA, P < 0.05) in LCMV-Arm– and LCMV-Cl13–infected mice are labeled blue and red, respectively. Shown is one of two independent experiments with n = 5 mice per group. Data represent two independent experiments with five mice per group. (B) LCMV-Cl13–infected mice were treated at 60–80 dpi with isotype control antibody or antibodies against the IL-10 receptor, IL-17, IL-4 and IL-5, PDL1, or CTLA4. Box plots show virus titers in the SI and LI after blockade. *, P < 0.05 (t test). n = 10 mice per group from two independent experiments.