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. 2020 Aug 20;217(12):e20200513. doi: 10.1084/jem.20200513

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© 2020 Fichtner et al.

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Figure S5. — MuSK1A and MuSK1B are similar to sequence-related Fabs. MuSK1A and MuSK1B differ most substantially in the L CDR3 and H CDR3 loops compared with sequence-related Fabs from the PDB. (A) Superposition of VH and variable light chain (VL) domains of MuSK1A with related Fabs. PDB codes 3X3F, 3X3G, 5IES, 6DW2, 6ID4, 6MFP, 6P8N, 6MFJ, and 6PHF are aligned to the VH domain. PDB codes 4DAG, 4QHK, 4QHL, 4XNM, 4XNQ, 5ODB, 5Y2K, 6B0S, and 6EIB are aligned to the VL domain of MuSK1A. (B) Superposition of VH and VL domains of MuSK1B with related Fabs. PDB codes 1QLR, 3B2U, 4R4B, 5DRW, 5SX4, 5DRX, 6MLK, 6MHR, 6II9, and 6B3S are aligned to the VH domain of MuSK1B. PDB codes 4AJ0, 4AIX, 4DAG, 4QHK, 4QHL, 4XWG, 5BV7, 5ODP, 5Y2K, 6BOS, and 6EIB are aligned to the VL domain of MuSK1B.