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. 2020 Sep 3;217(12):e20192276. doi: 10.1084/jem.20192276

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© 2020 Labarta-Bajo et al.

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Figure 6. — LCMV Cl13 infection enhances susceptibility to colitis induced by chemical or secondary pathogen insults. C57BL/6 mice were infected with LCMV Cl13 or ARM or left uninfected. At days 21 or 30 p.i., mice were treated with 2% wt/vol dextran sulfate sodium for 10 d consecutively (A) or i.o. infected with 3.5 × 10⁹ CFUs of C. rodentium (+C.rod) or left untreated (untx; B and C). Percentage of initial body weight (A and B) and survival curves (C) are shown. Averages (C) or averages ± SEM (A and B) are shown. Data are pooled from two (A) and representative of two (B and C) independent experiment with n = 3–5 mice/group. (A) One-way ANOVA with Tukey’s multiple comparisons correction on day 31 p.i. (B) One-way ANOVA with Dunnett’s multiple comparisons test with ARM+C.rod and Cl13+C.rod versus Un+C.rod at every time point p.i. (C) Log-rank Mantel–Cox survival test. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.