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. 2020 Aug 28;217(12):e20190354. doi: 10.1084/jem.20190354

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© 2020 Zhang et al.

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Figure 1. — IL17-secreting cells are increased in murine and human pancreatic adenocarcinoma carcinoma. (A) Heat map representing serum levels of cytokines from a spontaneous pancreatic adenocarcinoma mouse model (KPC) and control mice (Pdx1-Cre) at 1 mo and 6 mo of age. (B) Serum IL17 levels measured by Luminex assay in Pdx-Cre and KPC mice at 1 mo and 6 mo of age. Results show the mean ± SD of fold changes from KPC over Pdx-Cre (n = 5). (C) Relative IL17 mRNA expression measured by quantitative RT-PCR in normal pancreatic tissue and tumor tissue formed from KPC cells orthotopically implanted into syngeneic mice. Results show the mean ± SD of fold changes from KPC tumors over normal pancreas (n = 5). (D) Th17 cells in normal human pancreatic tissue and PDAC based on RORγt staining by IHC. Scale bars represent 50 µm. (E) Quantification of human RORγt⁺ cells on tissue from normal versus PDAC. (F) Kaplan-Meier survival curves comparing survival of patients with PDAC with low versus high levels of median IL17A expression. *, P < 0.05; ***, P < 0.001; ****, P < 0.0001.