Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 17;217(12):e20200474. doi: 10.1084/jem.20200474

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Liu et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 2. — Integrative multi-omic analysis demonstrates convergence at the APOE locus in mutant hMGLs. (A–D) APOE pathway network in individual hMGL lines. OmicsIntegrator network branches containing APOE is depicted from multi-omic TREM2 KO (A), TREM2^R47H (C), SORL1 KO (B), and SORL1^A528T (D) hMGL datasets. Color scheme for nodes identified by a particular analytical dataset is shown in A; node and font size are scaled according to identification across multi-omic datasets. APOE is intentionally marked with an increased font size, and adjacent nodes are highlighted. Gray nodes depict node inserts applied by the OmicsIntegrator algorithm to connect adjacent networks.