Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 17;217(12):e20200474. doi: 10.1084/jem.20200474

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Liu et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 7. — Modulation of transcription networks in AD-associated hMGLs. (A) Two transcriptionally active regions within the APOE locus identified by ATAC-seq were characterized for transcription factor (TF) motifs using PROMO. TFs were plotted for the two ATAC-seq peaks (nucleotides [nts] 1–227, Chr19:44905612; nts 1–133, Chr19:44906516) depicted in green. Number of predicted TFs in these two regions is indicated in the pie chart. (B) Upstream transcription factors with targets significantly enriched for genes dysregulated in all four -omics analytical datasets were plotted on the network map shown. Cell line–specific transcription factors are annotated by circles, and cell lines are annotated by squares in the network diagram. Shared transcription factors are connected to each cell line in which they are enriched. Some transcription factors are enriched in a single cell line (small yellow nodes), while others are enriched in two cell lines (light green), three cell lines (teal), or all four cell lines (dark purple). PU.1, NR3C1, and CEBPB are marked in large font on the Cytoscape map.