Fig. 7.

SOCS6 inhibits tumor growth and sensitizes ESCC tumors to radiation in xenograft animal models. a Eca109 cells expressing SOCS6 and control Eca109 cells were subcutaneously injected into nude mice (n = 5/group). The tumor volume was monitored every 4 days for 28 days. SOCS6 significantly inhibited tumor growth; b other mice were treated with radiation (2 Gy) when the tumor volume reached 100 mm³. The tumor size was measured 2 weeks later, and the tumor volume in the Eca109-SOCS6 group was decreased compared with that in the control group (n = 6/group). The statistical results are shown on the right. IR irradiation; c c-Kit was downregulated in tumors overexpressing SOCS6, as determined by IHC staining. The data are presented as mean ± SD, *P < 0.05, **P < 0.01 and ***P < 0.001