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. 2021 Mar 11;12:172. doi: 10.1186/s13287-021-02217-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — The recovery of locomotor function following stem cell transplantation after SCI. The locomotor function of PBS- or stem cell-treated mice was assessed using the BMS test: BMS score (a), subscore (b), coordination (c), trunk (d), and the stepping score of right side (e) and left side (f). All animals in the NSC group showed significantly higher performance in the open-field BMS test than MSC-treated animals and PBS controls (a). Significantly higher subscores were recorded for the NSC group than the other treatment groups. Additionally, the MSC-transplanted animals did not show better performance than controls (b). Regarding coordination (c), for which body weight-supported stepping is essential, a stable but insignificant trend of higher performance was observed in the NSC group. The trunk function in the NSC group recovered earlier and to a greater extent than the MSC and control groups (d). A stable but insignificant trend of higher performance on stepping function was observed in the NSC group after the grafting of stem cells (e, f). g–i, Mouse limb function at dpo 1; g′–i′, mouse limb function at dpo 28. *p < 0.05 compared with the control group; ^#p < 0.05 compared with the MSC group