Fig. 1. (A) Time course of the simultaneous evolving sensor response for each antigen in real time for a representative RNA(+) patient showing the combined IgM, IgG, and IgA response against membrane (Mem), spike (S) 1 and 2, nucleocapsid (N) and envelope (Env), and host proteins aCRP, total IgG (represented as the capture antigen Protein A/G (PAG)). The first set of responses (before 250 seconds) shows binding in response to patient serum exposure and the second set of responses the detection antibody (300–400 seconds) (B) The combined IgG, IgA and IgM sensor response in mRIU seconds is shown for each viral and host antigen integrated over 120 seconds. The total serum IgG level (represented as PAG in (A) is divided by 5 (C) Evolution of the IgM, IgG and IgA response for a single patient.