Table 7.
Clusters of MBHD-VD PPI network.
| Cluster | Score | Nodes | Edges | Targets and genes |
|---|---|---|---|---|
| 1 | 52.567 | 68 | 1761 | PIK3CD, PIK3CG, PIK3CA, IL1B, PLA2G1B, ERBB2, NGF, BDNF, MAPK14, MAPK9, CASP3, CAT, CSF2, GFAP, CALM1, TIMP1, EGFR, ESR1, CALM3, NOS3, STAT3, VEGFA, TNF, HSP90AA1, CALM2, ACE, IGF1, APOE, APP, TLR9, SERPINE1, ICAM1, MMP9, FGF2, NR3C1, TGFB1, REL, RELA, GAPDH, CREB1, JUN, AKT1, CASP9, BCL2, BCL2L1, PTGS2, MAPK8, MAPK3, CYCS, AR, KDR, FLT1, F2, CXCR4, FAS, IL6, NOS2, MAPK1, PLG, CASP8, PPARG, MT3, SRC, CD40, TF, STAT1, TNFRSF1A, MMP2 |
| 2 | 8 | 29 | 112 | ESR2, PRKCG, GRM5, FPR2, PLCB1, MAPT, GSK3A, PTAFR, FGFR1, SREBF1, GRM1, SOD1, LRRK2, CRH, FLT4, AVP, ITIH4, CHRM1, CDK5, NPY, HCK, HTR2A, ADRA1B, ADRA1A, S100B, ADRA1D, CHRM3, LGALS3, CHRM5 |
| 3 | 6 | 20 | 57 | CETP, APLP2, SLC6A3, IDE, OGT, SREBF2, BACE1, MBNL1, ECE1, AATF, APLP1, ABCA1, CSTB, NR1H3, NR1H2, HMGCR, TTR, LRP1, PTPRF, PRNP |
| 4 | 5.769 | 27 | 75 | FGF1, AGT, ERBB3, JUND, AKT2, NOS1, IL5, MET, MBP, LDLR, SYK, GSK3B, MCL1, PLAU, MMP3, MMP1, BCR, LYN, LCK, FYN, ADIPOQ, CDK4, CDK1, VWF, AGTR1, MMP13, HMOX1 |
| 5 | 5.667 | 25 | 68 | CHRM4, PRKCB, CHRM2, ERN1, ADORA1, SYP, SNCA, ACTC1, GRIN2B, CNR2, CNR1, HTR1B, LPL, HTR1A, APOA1, MAP2, PPP3CA, BLK, HSP90B1, GAL, FGR, F7, YES1, APOB, PRKCD |
| 6 | 4.8 | 6 | 12 | ALDH1A2, CRYZ, ALDH2, ALDH1A3, CBR3, CBR1 |
| 7 | 4 | 7 | 12 | VIP, SLC18A3, UBQLN2, ACHE, DNM1, PICALM, UBB |
| 8 | 4 | 5 | 8 | AKR1A1, AKR1B10, ALDH1L1, AKR1B15, ALDH1L2 |
| 9 | 3.667 | 7 | 11 | AOX1, MAOA, ALDH1B1, ALDH1A1, RDH8, AKR1B1, HSD11B1L |
| 10 | 3.5 | 13 | 21 | TOP2A, A2M, SERPINA3, FGFR3, DLG4, HSP90AB1, CLU, GRIN2A, PSEN1, GRIN1, APOH, ELANE, CTSB |
| 11 | 3.2 | 6 | 8 | PRKCA, MAPK11, ADAM17, ERBB4, GDNF, NGFR |
| 12 | 3 | 3 | 3 | GLI3, GLI2, GLI1 |
| 13 | 3 | 5 | 6 | DLST, MT-CO1, DHFRL1, SDHB, DHFR |
| 14 | 3 | 3 | 3 | LBR, CYP46A1, CYP51A1 |