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. 2021 Feb 25;11:613328. doi: 10.3389/fphar.2020.613328

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Copyright © 2021 Safa, Lau, Aten, Schilling, Bales, Miller, Fitzgerald, Chen, Hill, Dzwigalski, Obrietan, Phelps, Sadee and Oberdick.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dose-dependent effect of 6BN using normalized composite outcome scores. Pups at 48 hr after birth were placed in the open-field arena for 10 min and video recorded. (A) Data for distance traveled, total freezing time, number of calls in 10 min, and call SNR (“loudness”) were merged to generate composite outcome scores (see text for details). (B) Same as A, but without “number of calls” as a factor in composite score. In (A), (B): p < 0.05 for overall effect of 6BN by linear trend test; *p < 0.05 compared to “0 6BN”, by Dunnett post-hoc test; ^yy p < 0.01 for “0 6BN” compared to saline control (grey lines, mean±SEM). An average of 16 pups from 8 litters was used in each dosage group.