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. 2021 Feb 25;11:613328. doi: 10.3389/fphar.2020.613328

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Copyright © 2021 Safa, Lau, Aten, Schilling, Bales, Miller, Fitzgerald, Chen, Hill, Dzwigalski, Obrietan, Phelps, Sadee and Oberdick.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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6BN has high potency to prevent opioid withdrawal in adult guinea pigs. Animals were treated for 3 days with one injection per day of 10 mg/kg MTD with varying doses of 6BN (0, 0.01, 0.03, 0.3, and 1 mg/kg). On day 4 animals were injected with naloxone and tested for 30 min in an open-field arena. (A) 6BN delivered at low doses with MTD prevents naloxone-induced withdrawal in adult animals. p < 0.05 for overall effect of 6BN, by linear trend test. (B) Same as A, but three animals with >15% of total arena-time in hypotonic posture were removed from dataset. p < 0.01 for overall effect of 6BN, by linear trend test. (A), (B) *p < 0.05, **p < 0.01, ***p < 0.001, compared to “0 6BN” control, by Dunnett post-hoc test; ψp < 0.05 compared to saline control (gray lines, mean ± SEM), by t-test.