TABLE 1.
Plasma PK analysis and bioavailability of 6BN.
| Parameters | Unit | IV (10 mg/kg) | PO (40 mg/kg) |
|---|---|---|---|
| n = 3 | n = 4 | ||
| T1/2 | hr | 1.12 (0.75,1.43) | 2.06 (1.17,2.68) |
| CO | ng/ml | 3,280 ± 3,300 | |
| Cmax | ng/ml | 647 ± 279 | |
| Tmax | hr | 0.25 (0.25,0.5) | |
| VSS | L/kg | 7.27 ± 4.29 | |
| CL | ml/min/kg | 132 ± 56 | |
| AUClast | hr*ng/ml | 1,450 ± 861 | 1,620 ± 540 |
| AUVinf | hr*ng/ml | 1,490 ± 830 | 1710 ± 513 |
| Bioavailability a | 28.7 |
a
Bioavailability was calculated with AUCinf and nominal doses.
Values are geometric mean (geometric SD) except for t1/2 and Tmax values are median (min, max).