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6BN mean plasma unbound fraction.
| [6BN], nM | Mouse | SD | Rat | SD | Guinea pig | SD | Dog | SD | Human | SD | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.5 | 96.5 | 3.36 | 83.5 | 13.10 | 93.7 | 5.53 | 93.2 | 9.40 | 94.3 | 5.22 | |
| 1.5 | 96.4 | 3.08 | 90.7 | 7.60 | 82.0 | 3.17 | 90.3 | 11.30 | 90.5 | 6.93 | |
| 5 | 90.5 | 6.52 | 91.3 | 4.83 | 94.5 | 8.54 | 94.7 | 6.36 | 95.7 | 5.13 | |
| 15 | 97.2 | 4.11 | 87.4 | 10.00 | 89.4 | 8.37 | 90.6 | 13.60 | 77.2 | 0.53 | |
| 50 | 92.7 | 5.22 | 92.4 | 9.27 | 95.3 | 5.85 | 90.1 | 12.40 | 93.6 | 7.56 | |
| avg | 94.7 | 89.1 | 91.0 | 91.8 | 90.3 | ||||||
