TABLE 4.
Effect of methadone on maternal weight gain and litter size.
| MTD dose (mg/kg) | n = | Start weight (g) | End weight (g) | Weight gain (g) | % Weight gain | AVG litter size | Total pup # | Total pup deaths |
|---|---|---|---|---|---|---|---|---|
| 2 | 2 | 1,084 ± 40 | 1,221 ± 61 | 136 ± 21b | 12.5 ± 1.5 | 3.0 + 1.0 | 6 | 0 |
| 5 | 8 | 1,195 ± 45 | 1,312 ± 64 | 118 ± 27b | 9.7 ± 2.0 | 5.0 + 0.4 | 42 | 1 |
| 7 | 2 | 1,174 ± 50 | 1,295 ± 115 | 121 ± 65b | 10.1 ± 5.1 | 4.0 + 1.0 | 8 | 0 |
| 10 | 5 | 1,214 ± 28 | 1,205 ± 11.9 | −9.2 ± 24.4 a | -0.6 ± 2.0 | 3.8 + 0.7 | 19 | 7 |
| 12 | 2 | 1,335 ± 11 | 1,160 ± 5 | −175 ± 6 a | -13.1 ± 0.3 | ND | 5 | 5 |
| 0 (saline ctl) | 5 | 1,188 ± 36 | 1,395 ± 31 | 206 ± 34 | 17.7 ± 3.4 | 5.8 + 0.6 | 29 | 3 |
All values ± SEM. F(5,18) = 55.66, p < 0.0001, for overall effect of MTD on maternal weight gain.
a
p < 0.001 compared to saline controls, by Dunnetts posthoc test.
bIf data at 2, 5, and 7 mg/kg are pooled as a single group then F(3,20) = 89.66, p < 0.0001, for overall effect of MTD, by ANOVA; for individual comparisons p = 0.056 compared to saline control, by Dunnetts posthoc test.