TABLE 6.
The effect of 6BN on maternal weight gain and litter size.
| 6BN dose (mg/kg) | MTD dose (mg/kg) | n = | Start weight (g) | End weight (g) | Weight gain (g) | % Weight gain | AVG litter size | Total pup # | Total pup deaths |
|---|---|---|---|---|---|---|---|---|---|
| 0 | 5,7 | 10 (8 at 5 MTD; 2 at 7 MTD) | 1,190 ± 37 | 1,309 ± 53 | 118 ± 23** | 9.7 ± 1.8 | 4.5 ± 0.4 | 48 | 1 |
| 0.025 | 5 | 6 | 1,252 ± 69 | 1,389 ± 61 | 137.5 ± 69 | 11.9 ± 5.1 | 4.2 ± 1.0 | 25 | 4 |
| 0.075 | 5,7 | 8 (6 at 5 MTD; 2 at 7 MTD) | 1,230 ± 52 | 1,355 ± 51 | 125.9 ± 26 | 10.7 ± 2.5 | 4.3 ± 0.6 | 34 | 4 |
| 0.3 | 5,7 | 7 (5 at 5 MID; 2 at 7 MTD) | 1,188 ± 35 | 1,349 ± 49 | 163 ± 24 | 13.7 ± 2.0 | 4.5 ± 0.7 | 27 | 1 |
| 0.3 | 0 | 2 | 1,134 ± 17 | 1,481 ± 25 | 347 ± 8* | 30.6 ± 0.2 | 5.5 ± 0.5 | 11 | 0 |
| 0 (saline ctl) | 0 | 5 | 1,188 ± 36 | 1,395 ± 31 | 206 ± 34 | 17.7 ± 3.4 | 5.8 ± 0.6 | 29 | 3 |
All values ± SEM. No overall significant effect of 6BN on maternal weight gain, by ANOVA; *p < 0.05, compared to saline control by t-test; **p = 0.0664, compared to saline control, by t-test.